Optics is foundational to research in many areas of science and engineering, including nanophotonics, quantum information, materials science, biomedical imaging, and metrology. However, the design, assembly, and alignment of optical experiments remain predominantly manual, limiting throughput and reproducibility. Automating such experiments is challenging due to the strict, non-negotiable precision requirements and the diversity of optical configurations found in typical laboratories. Here, we introduce a platform that integrates generative artificial intelligence, computer vision, and robotics to automate free-space optical experiments. The platform translates user-defined goals into valid optical configurations, assembles them using a robotic arm, and performs micrometer-scale fine alignment using a robot-deployable tool. It then executes a range of automated measurements, including beam characterization, polarization mapping, and spectroscopy, with consistency surpassing that of human operators. This work demonstrates the first flexible, AI-driven automation platform for optics, offering a path towards remote operation, cloud labs, and high-throughput discovery in the optical sciences.

Optical quantum sensing promises measurement precision beyond classical sensors termed the Heisenberg limit (HL). However, conventional methodologies often rely on prior knowledge of the target system to achieve HL, presenting challenges in practical applications. Addressing this limitation, we introduce an innovative Deep Learning-based Quantum Sensing scheme (DQS), enabling optical quantum sensors to attain HL in agnostic environments. DQS incorporates two essential components: a Graph Neural Network (GNN) predictor and a trigonometric interpolation algorithm. Operating within a data-driven paradigm, DQS utilizes the GNN predictor, trained on offline data, to unveil the intrinsic relationships between the optical setups employed in preparing the probe state and the resulting quantum Fisher information (QFI) after interaction with the agnostic environment. This distilled knowledge facilitates the identification of optimal optical setups associated with maximal QFI. Subsequently, DQS employs a trigonometric interpolation algorithm to recover the unknown parameter estimates for the identified optical setups. Extensive experiments are conducted to investigate the performance of DQS under different settings up to eight photons. Our findings not only offer a new lens through which to accelerate optical quantum sensing tasks but also catalyze future research integrating deep learning and quantum mechanics.

How useful can machine learning be in a quantum laboratory? Here we raise the question of the potential of intelligent machines in the context of scientific research. A major motivation for the present work is the unknown reachability of various entanglement classes in quantum experiments. We investigate this question by using the projective simulation model, a physics-oriented approach to artificial intelligence. In our approach, the projective simulation system is challenged to design complex photonic quantum experiments that produce high-dimensional entangled multiphoton states, which are of high interest in modern quantum experiments. The artificial intelligence system learns to create a variety of entangled states, and improves the efficiency of their realization. In the process, the system autonomously (re)discovers experimental techniques which are only now becoming standard in modern quantum optical experiments - a trait which was not explicitly demanded from the system but emerged through the process of learning. Such features highlight the possibility that machines could have a significantly more creative role in future research.